BDBM195867 US9670213, Compound 012 4-(dimethylamino)-N-(4-(7-oxo-2-(phenylamino)-8(7H)-pteridin-yl)phenyl)-2-buteneamide

SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)-n1c2nc(Nc3ccccc3)ncc2ncc1=O

InChI Key InChIKey=KGPLGVFZWCSDMU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 195867   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195867(US9670213, Compound 012 4-(dimethylamino)-N-(4-(7-...)
Affinity DataIC50: 160nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195867(US9670213, Compound 012 4-(dimethylamino)-N-(4-(7-...)
Affinity DataIC50: 1.92E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195867(US9670213, Compound 012 4-(dimethylamino)-N-(4-(7-...)
Affinity DataIC50: 5.34E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195867(US9670213, Compound 012 4-(dimethylamino)-N-(4-(7-...)
Affinity DataIC50: 5.98E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetTyrosine-protein kinase Blk(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195867(US9670213, Compound 012 4-(dimethylamino)-N-(4-(7-...)
Affinity DataIC50: 6.32E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent