BDBM228671 US10369153, Compound 77::US9346810, 77

SMILES Cc1cc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)ncc1[N+](=O)[O-]

InChI Key InChIKey=CCNHWVJXLXJKFD-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 228671   

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Hutchison Medipharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228671BDBM228671(US9346810, 77 | US10369153, Compound 77)
Affinity DataIC50: 0.0550nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Hutchison Medipharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228671BDBM228671(US9346810, 77 | US10369153, Compound 77)
Affinity DataIC50: 0.550nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Hutchison Medipharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228671BDBM228671(US9346810, 77 | US10369153, Compound 77)
Affinity DataIC50: 0.550nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Hutchison Medipharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228671BDBM228671(US9346810, 77 | US10369153, Compound 77)
Affinity DataIC50: 100nMAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Hutchison Medipharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228671BDBM228671(US9346810, 77 | US10369153, Compound 77)
Affinity DataIC50: 550nMAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Hutchison Medipharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228671BDBM228671(US9346810, 77 | US10369153, Compound 77)
Affinity DataIC50: 550nMAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent