BDBM229784 US12522579, Entry THK-5470

SMILES Cc1ccc(-c2ccc3cc(OC[C@H](O)CF)ccc3n2)cn1

InChI Key InChIKey=FBXCMFBJUZVBJS-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 229784   

TargetAmine oxidase [flavin-containing] B(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 229784BDBM229784(US12522579, Entry THK-5470)
Affinity DataKd:  3.70nMAssay Description:Binding affinity to recombinant MAO-B (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 229784BDBM229784(US12522579, Entry THK-5470)
Affinity DataIC50: 4.20nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 229784BDBM229784(US12522579, Entry THK-5470)
Affinity DataIC50: 59nMAssay Description:Inhibition of human recombinant MAO-B incubated for 30 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Tohoku University

US Patent
LigandChemical structure of BindingDB Monomer ID 229784BDBM229784(US12522579, Entry THK-5470)
Affinity DataIC50: 713nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Tohoku University

US Patent
LigandChemical structure of BindingDB Monomer ID 229784BDBM229784(US12522579, Entry THK-5470)
Affinity DataIC50: 4.46E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details
US Patent