BDBM245641 US9428508, 96

SMILES COc1cc(ccc1Nc1nc2NCCc2c(Nc2ccccc2S(=O)(=O)NC(C)C)n1)N1CCC(CC1)N1CCN(C)CC1

InChI Key InChIKey=NPJCURIANJMFEO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 245641   

TargetFocal adhesion kinase 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 245641BDBM245641(US9428508, 96)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of TACE by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetFocal adhesion kinase 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 245641BDBM245641(US9428508, 96)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of FLT3 phosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 245641BDBM245641(US9428508, 96)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human RSK2-mediated CREB phosphorylation in HLR-CREB cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetALK tyrosine kinase receptor(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 245641BDBM245641(US9428508, 96)
Affinity DataIC50: 2.40nMAssay Description:in vitro cell based assay for measuring the IC50 values of osteoblast resorption.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 245641BDBM245641(US9428508, 96)
Affinity DataIC50: 11nMAssay Description:Inhibition of human RSK2-mediated CREB phosphorylation in HLR-CREB cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 245641BDBM245641(US9428508, 96)
Affinity DataIC50: 20nMAssay Description:To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 245641BDBM245641(US9428508, 96)
Affinity DataIC50: 20nMAssay Description:To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
US Patent