BDBM25002 4-[7-(3-aminopropoxy)-4-(2-cyclopropylethynyl)-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine::oxadiazole-containing compound, 12a

SMILES CCn1c(nc2c(ncc(OCCCN)c12)C#CC1CC1)-c1nonc1N

InChI Key InChIKey=UBGKZPSSXPFLIM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 25002   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Glaxosmithkline

LigandChemical structure of BindingDB Monomer ID 25002BDBM25002(4-[7-(3-aminopropoxy)-4-(2-cyclopropylethynyl)-1-e...)
Affinity DataIC50: 79nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2008
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Glaxosmithkline

LigandChemical structure of BindingDB Monomer ID 25002BDBM25002(4-[7-(3-aminopropoxy)-4-(2-cyclopropylethynyl)-1-e...)
Affinity DataIC50: 251nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2008
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandChemical structure of BindingDB Monomer ID 25002BDBM25002(4-[7-(3-aminopropoxy)-4-(2-cyclopropylethynyl)-1-e...)
Affinity DataIC50: 2.00E+3nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2008
Entry Details Article
PubMed