BDBM264116 3-(4-(4-(4-(1-oxoisoquinolin-2(1H)-yl)phenyl)piperazin-1-yl)butyl)-1H-indole-5-carbonitrile::US9714232, 29

SMILES O=c1n(ccc2ccccc12)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1

InChI Key InChIKey=AMDZNENPETWKSQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 264116   

TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264116(3-(4-(4-(4-(1-oxoisoquinolin-2(1H)-yl)phenyl)piper...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM264116(3-(4-(4-(4-(1-oxoisoquinolin-2(1H)-yl)phenyl)piper...)
Affinity DataIC50:  10nMpH: 7.4Assay Description:The synaptosomes (150 μg) prepared from a rat brain were incubated at 37° C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent