BDBM27443 5-(1H-1,3-benzodiazol-1-yl)-3-[(4-methylphenyl)methoxy]thiophene-2-carboxamide::BMCL191018 Compound 9::benzimidazole-thiophene carboxamide, 1

SMILES Cc1ccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)cc1

InChI Key InChIKey=LGVVNIMZHUYDAQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 27443   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Gsk

LigandPNGBDBM27443(5-(1H-1,3-benzodiazol-1-yl)-3-[(4-methylphenyl)met...)
Affinity DataIC50:  70nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Gsk

LigandPNGBDBM27443(5-(1H-1,3-benzodiazol-1-yl)-3-[(4-methylphenyl)met...)
Affinity DataIC50:  126nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK1 and biotinylated peptide substrate in the presence ATP/[gamma-33P]AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27443(5-(1H-1,3-benzodiazol-1-yl)-3-[(4-methylphenyl)met...)
Affinity DataIC50:  3.98E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed