BDBM276462 1-(3,4-dichloro-2-methoxy-5,6,7,9- tetrahydro-8H-pyrrolo[3,2-b:4,5-c']dipyridin- 8-yl)-2-hydroxyethan-1-one::US12522603, Example 1

SMILES COc1nc2c3c([nH]c2c(Cl)c1Cl)CCN(C(=O)CO)C3

InChI Key InChIKey=CHMDNJKBNOXRKS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 276462   

TargetMannosyl-oligosaccharide glucosidase(Human)
The Rockefeller University; Memorial Sloan-Kettering Cancer Center

US Patent
LigandChemical structure of BindingDB Monomer ID 276462BDBM276462(1-(3,4-dichloro-2-methoxy-5,6,7,9- tetrahydro-8H-...)
Affinity DataIC50: 61.6nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
The Rockefeller University; Memorial Sloan-Kettering Cancer Center

US Patent
LigandChemical structure of BindingDB Monomer ID 276462BDBM276462(1-(3,4-dichloro-2-methoxy-5,6,7,9- tetrahydro-8H-...)
Affinity DataIC50: 190nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details
US Patent