BDBM27887 4-{[2-(4-chloro-1H-pyrazol-1-yl)ethyl]amino}-3-{6-[1-(2-methoxyethyl)piperidin-4-yl]-4-methyl-1H-1,3-benzodiazol-2-yl}-1,2-dihydropyridin-2-one::benzimidazole scaffold, 9

SMILES COCCN1CCC(CC1)c1cc(C)c2nc([nH]c2c1)-c1c(NCCn2cc(Cl)cn2)cc[nH]c1=O

InChI Key InChIKey=SVKIVWVOFVHFNK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 27887   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM27887(4-{[2-(4-chloro-1H-pyrazol-1-yl)ethyl]amino}-3-{6-...)
Affinity DataIC50:  1.95E+4nMpH: 7.4 T: 2°CAssay Description:The inhibition of recombinant human CYP3A4 was measured as the ability to perform a dealkylation of 7-benzyloxy-4-trifluoromethylcoumarin (BFC). Befo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM27887(4-{[2-(4-chloro-1H-pyrazol-1-yl)ethyl]amino}-3-{6-...)
Affinity DataIC50:  18nMpH: 7.0 T: 2°CAssay Description:The IGF-1 receptor tyrosine kinase was assayed using the synthetic polymer poly(Glu/Tyr) as a phosphoacceptor substrate. Incorporated radioactivity w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed