BDBM3058 2-(cyclohexylamino)-6-(2,6-dichlorophenyl)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one::2-Cyclohexylamino-6-(2,6-dichlorophenyl)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one::2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 25::PD 166285 analog

SMILES Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(NC3CCCCC3)nc21

InChI Key InChIKey=SPPVVBKDFLCZFT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 3058   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Parke-Davis Pharmaceutical Research

LigandChemical structure of BindingDB Monomer ID 3058BDBM3058(2-Cyclohexylamino-6-(2,6-dichlorophenyl)-8-methyl-...)
Affinity DataIC50: 1.60E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandChemical structure of BindingDB Monomer ID 3058BDBM3058(2-Cyclohexylamino-6-(2,6-dichlorophenyl)-8-methyl-...)
Affinity DataIC50: 6.80E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2005
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Parke-Davis Pharmaceutical Research

LigandChemical structure of BindingDB Monomer ID 3058BDBM3058(2-Cyclohexylamino-6-(2,6-dichlorophenyl)-8-methyl-...)
Affinity DataIC50: 1.25E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandChemical structure of BindingDB Monomer ID 3058BDBM3058(2-Cyclohexylamino-6-(2,6-dichlorophenyl)-8-methyl-...)
Affinity DataIC50: 5.00E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2005
Entry Details Article
PubMed