BDBM360980 (R)-4'-(methylsulfonamido)-N4- (pyrrolidin-3-yl)-2-(1H-tetrazol- 5-yl)-[1,1'-biphenyl]-3,4- disulfonamide::US10221163, Example 136::US10544130, Example 136

SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1

InChI Key InChIKey=SSQJGJDTNDSZCF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 360980   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 360980BDBM360980(US10221163, Example 136 | (R)-4'-(methylsulfonamid...)
Affinity DataIC50: 0.0370nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 360980BDBM360980(US10221163, Example 136 | (R)-4'-(methylsulfonamid...)
Affinity DataIC50: 0.0370nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 360980BDBM360980(US10221163, Example 136 | (R)-4'-(methylsulfonamid...)
Affinity DataIC50: 0.0750nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 360980BDBM360980(US10221163, Example 136 | (R)-4'-(methylsulfonamid...)
Affinity DataIC50: 0.0750nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 360980BDBM360980(US10221163, Example 136 | (R)-4'-(methylsulfonamid...)
Affinity DataIC50: 0.105nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 360980BDBM360980(US10221163, Example 136 | (R)-4'-(methylsulfonamid...)
Affinity DataIC50: 0.105nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent