BDBM366815 N-methyl-4-[[8-[1-(3- methylbutanoyl)-3,6- dihydro-2H-pyridin-4- yl]-[1,2,4]triazolo[1,5- a]pyridin-2-yl]amino]- N-(1-methyl-4- piperidyl)benzamide::US9873709, Example 2-109

SMILES CC(C)CC(=O)N1CCC(=CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)N(C)C3CCN(C)CC3)nc12

InChI Key InChIKey=XIIUWQNLDXWWML-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366815   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM366815(N-methyl-4-[[8-[1-(3- methylbutanoyl)-3,6- dihydro...)
Affinity DataKi:  0.980nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM366815(N-methyl-4-[[8-[1-(3- methylbutanoyl)-3,6- dihydro...)
Affinity DataKi:  5.02nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent