BDBM369243 US12528814, Example 27

SMILES CC(C)Nc1cc(-c2ccc3cc(C#N)cnn23)ncc1-c1nnc(N2CCN(CCCc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)s1

InChI Key InChIKey=OOHVUYKPMTXNOD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 369243   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Nurix Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 369243BDBM369243(US12528814, Example 27)
Affinity DataIC50: 0.300nMAssay Description:The binding capacities of certain bifunctional compounds of Formula (I) were determined using the CisBio HTRF KinEASE STK S1 Kit (#62ST1PEB, contains...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2026
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Nurix Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 369243BDBM369243(US12528814, Example 27)
Affinity DataIC50: 1.20nMAssay Description:The binding capacities of certain bifunctional compounds of Formula (I) were determined using the CisBio HTRF KinEASE STK S1 Kit (#62ST1PEB, contains...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2026
Entry Details
US Patent