BDBM372281 US20260021085, Compound 28

SMILES Cc1ccccc1[C@H](NC(=O)[C@@H]1CCC[C@@H]1C(=O)O)c1ccc(C2CCC2)cc1

InChI Key InChIKey=NGZHRLQKDOTEEF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372281   

TargetGlycogen [starch] synthase, muscle/Glycogenin-1 (GN1)(Human)
Maze Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 372281BDBM372281(US20260021085, Compound 28)
Affinity DataIC50: 224nMAssay Description:Compounds that inhibit the hGYS1 enzyme and, subsequently, the downstream conversion of NADH to NAD+, were tested using assay ready plates (black, cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent

TargetGlycogen [starch] synthase, liver/Glycogenin-1 (GN1)(Human)
Maze Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 372281BDBM372281(US20260021085, Compound 28)
Affinity DataIC50: 7.80E+3nMAssay Description:Compounds that inhibit the hGYS2 enzyme and, subsequently, the downstream conversion of NADH to NAD+, were tested using assay ready plates (black, cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent