BDBM384817 N-{(1R)-1-[4- (difluoromethoxy)phenyl]-2- methylpropyl}-2-(dimethylamino)-6- oxo-1,6-dihydropyrimidine-4- carboxamide::US10285989, Example 33

SMILES CC(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)N(C)C)c1ccc(OC(F)F)cc1

InChI Key InChIKey=AOPGJDLENCUTSP-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384817   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384817(N-{(1R)-1-[4- (difluoromethoxy)phenyl]-2- methylpr...)
Affinity DataKi:  2nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384817(N-{(1R)-1-[4- (difluoromethoxy)phenyl]-2- methylpr...)
Affinity DataKi:  2.70nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent