BDBM391934 N1-(3',4'-dihydro-2'H- spiro[cyclopropane-1,1'- naphthalen]-2-yl)propane- 1,3-diamine::US10301253, Example 86

SMILES NCCCNC1CC11CCCc2ccccc12

InChI Key InChIKey=HETFVNZVXVXVLC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391934   

TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391934(N1-(3',4'-dihydro-2'H- spiro[cyclopropane-1,1'- na...)
Affinity DataIC50:  199nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391934(N1-(3',4'-dihydro-2'H- spiro[cyclopropane-1,1'- na...)
Affinity DataIC50:  253nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent