BDBM4183 1,6-naphthyridin-2(1H)-one deriv. 7p::3-(2,6-Dichlorophenyl)-7-[(4-methoxyphenyl)amino]-1-methyl-1,6-naphthyridin-2(1H)-one::3-(2,6-dichlorophenyl)-7-[(4-methoxyphenyl)amino]-1-methyl-1,2-dihydro-1,6-naphthyridin-2-one

SMILES COc1ccc(Nc2cc3c(cn2)cc(-c2c(Cl)cccc2Cl)c(=O)n3C)cc1

InChI Key InChIKey=QQLWYDYVUOBKGW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4183   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Auckland

LigandChemical structure of BindingDB Monomer ID 4183BDBM4183(3-(2,6-dichlorophenyl)-7-[(4-methoxyphenyl)amino]-...)
Affinity DataIC50: 1.80E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
University of Auckland

LigandChemical structure of BindingDB Monomer ID 4183BDBM4183(3-(2,6-dichlorophenyl)-7-[(4-methoxyphenyl)amino]-...)
Affinity DataIC50: 2.20E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2005
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Auckland

LigandChemical structure of BindingDB Monomer ID 4183BDBM4183(3-(2,6-dichlorophenyl)-7-[(4-methoxyphenyl)amino]-...)
Affinity DataIC50: 6.80E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2005
Entry Details Article
PubMed