BDBM4350 (2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid::benzylidenemalononitrile (BMN) deriv. 34

SMILES OC(=O)C(=C\c1ccc(O)cc1)\C#N

InChI Key InChIKey=AFVLVVWMAFSXCK-VMPITWQZSA-N

Data  1 KI  9 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 4350   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM4350((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid ...)
Affinity DataKi:  1.65E+5nM IC50:  3.08E+5nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 35(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM4350((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid ...)
Affinity DataEC50:  9.80E+3nMAssay Description:Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 35(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM4350((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid ...)
Affinity DataEC50:  7.07E+4nMAssay Description:Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactmas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 35(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM4350((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid ...)
Affinity DataIC50:  3.04E+4nMAssay Description:Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 4(Homo sapiens (Human))TBA
LigandPNGBDBM4350((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid ...)
Affinity DataIC50: >1.50E+5nMAssay Description:Inhibition of MCT4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMonocarboxylate transporter 1(Rattus norvegicus (Rat))
Physiologisch-Chemisches Institut Der Eberhard-Karls-Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM4350((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid ...)
Affinity DataIC50:  4.25E+5nMAssay Description:TP_TRANSPORTER: inhibition of lactate uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 4(Homo sapiens (Human))TBA
LigandPNGBDBM4350((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid ...)
Affinity DataIC50:  9.91E+5nMAssay Description:TP_TRANSPORTER: inhibition of L-Lactate uptake (L-Lactate:30mM) in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Rattus norvegicus (Rat))
Physiologisch-Chemisches Institut Der Eberhard-Karls-Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM4350((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid ...)
Affinity DataIC50:  281nMAssay Description:Inhibition of MCT1 in rat RBE4 cells assessed as reduction in [14C]lactate uptake measured after 15 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))TBA
LigandPNGBDBM4350((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid ...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of MCT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM4350((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid ...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 2(Rattus norvegicus)
Physiologisch-Chemisches Institut Der Eberhard-Karls-Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM4350((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid ...)
Affinity DataIC50:  2.40E+4nMAssay Description:TP_TRANSPORTER: inhibition of lactate uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed