BDBM470525 N-(2-chloro-6-fluorophenyl)-2-{[3,3-difluorobutan-2-yl]oxy}-4-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-5-fluorobenzamide (Racemic)::US10815215, Example 185::US11130745, Example 185::US11713304, Example 185

SMILES CCn1c(CO)nn(-c2cc(OC(C)C(C)(F)F)c(cc2F)C(=O)Nc2c(F)cccc2Cl)c1=O

InChI Key InChIKey=OJOSDKQHTYFNOL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 470525   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengellschaft

US Patent
LigandPNGBDBM470525(N-(2-chloro-6-fluorophenyl)-2-{[3,3-difluorobutan-...)
Affinity DataIC50: 10nMAssay Description:The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller et al., 19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengellschaft

US Patent
LigandPNGBDBM470525(N-(2-chloro-6-fluorophenyl)-2-{[3,3-difluorobutan-...)
Affinity DataIC50: 10nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengellschaft

US Patent
LigandPNGBDBM470525(N-(2-chloro-6-fluorophenyl)-2-{[3,3-difluorobutan-...)
Affinity DataIC50: 10nMAssay Description:DHODH enzymatic assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent