BDBM50037060 CHEMBL3355311

SMILES Cc1cc(Nc2cc(Cc3ccccc3)nc(N[C@H]3CC[C@H](O)CC3)n2)n[nH]1

InChI Key

Data  1 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50037060   

TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Evotec

Curated by ChEMBL

LigandBDBM50037060(CHEMBL3355311)Copy SMILES

Affinity DataKi:  53nMAssay Description:Inhibition of GST-tagged full-length ITK (unknown origin) using Ac-EFPIYDFLPAKKK-NH2 as substrate after 35 mins by LC/MS analysisMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

Target1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1(Homo sapiens (Human))
Evotec

Curated by ChEMBL

LigandBDBM50037060(CHEMBL3355311)Copy SMILES

Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of PLC gamma-1 phosphorylation in human Jurkat T cells after 30 minsMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI