BDBM50092330 CHEMBL3581649::US9675697, RX-3

SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(Cl)c21

InChI Key InChIKey=HQWHFYOMOHBRTB-UHFFFAOYSA-N

Data  8 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50092330   

TargetBromodomain-containing protein 3 [326-398](Human)
University of Michigan

US Patent
LigandPNGBDBM50092330(US9675697, RX-3 | CHEMBL3581649)
Affinity DataKi:  64nM ΔG°:  -9.81kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 2 [364-436](Human)
University of Michigan

US Patent
LigandPNGBDBM50092330(US9675697, RX-3 | CHEMBL3581649)
Affinity DataKi:  109nM ΔG°:  -9.49kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3 [51-123](Human)
University of Michigan

US Patent
LigandPNGBDBM50092330(US9675697, RX-3 | CHEMBL3581649)
Affinity DataKi:  144nM ΔG°:  -9.33kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 2 [364-436](Human)
University of Michigan

US Patent
LigandPNGBDBM50092330(US9675697, RX-3 | CHEMBL3581649)
Affinity DataKi:  194nM ΔG°:  -9.15kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50092330(US9675697, RX-3 | CHEMBL3581649)
Affinity DataKi:  194nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD2 (333 to 460 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 2 [91-163](Human)
University of Michigan

US Patent
LigandPNGBDBM50092330(US9675697, RX-3 | CHEMBL3581649)
Affinity DataKi:  215nM ΔG°:  -9.09kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
University of Michigan

US Patent
LigandPNGBDBM50092330(US9675697, RX-3 | CHEMBL3581649)
Affinity DataKi:  305nM ΔG°:  -8.88kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50092330(US9675697, RX-3 | CHEMBL3581649)
Affinity DataKi:  305nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD1 (44 to 168 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50092330(US9675697, RX-3 | CHEMBL3581649)
Affinity DataIC50: 579nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD2 (333 to 460 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50092330(US9675697, RX-3 | CHEMBL3581649)
Affinity DataIC50: 862nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD1 (44 to 168 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed