BDBM50135570 3-(3,4-Dimethoxy-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester::CHEMBL335423

SMILES COC(=O)C1C2CCC(CC1c1ccc(OC)c(OC)c1)N2C

InChI Key InChIKey=KXYMHOPZXNZJHG-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50135570   

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50135570(3-(3,4-Dimethoxy-phenyl)-8-methyl-8-aza-bicyclo[3....)
Affinity DataKi:  46nMAssay Description:Ability to inhibit the binding of [125I]RT155 to Serotonin transporter in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50135570(3-(3,4-Dimethoxy-phenyl)-8-methyl-8-aza-bicyclo[3....)
Affinity DataKi:  1.54E+3nMAssay Description:Ability to inhibit the binding of [125I]RT155 to hDAT in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50135570(3-(3,4-Dimethoxy-phenyl)-8-methyl-8-aza-bicyclo[3....)
Affinity DataKi:  4.50E+3nMAssay Description:Ability to inhibit the binding of [125I]RT155 to hNET in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50135570(3-(3,4-Dimethoxy-phenyl)-8-methyl-8-aza-bicyclo[3....)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of [3H]norepinephrine uptake in HEK cells expressing human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50135570(3-(3,4-Dimethoxy-phenyl)-8-methyl-8-aza-bicyclo[3....)
Affinity DataIC50:  23nMAssay Description:Inhibition of [3H]5-HT uptake in HEK cells expressing human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50135570(3-(3,4-Dimethoxy-phenyl)-8-methyl-8-aza-bicyclo[3....)
Affinity DataIC50:  1.57E+3nMAssay Description:Ability to inhibit the binding of [H]norepinephrine to Norepinephrine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed