BDBM50140103 (S)-1-(2,6-difluorobenzyl)-3-(2-(cyclopentylamino)propyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione::3-((S)-2-Cyclopentylamino-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione::CHEMBL22653

SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C)NC2CCCC2)c1=O

InChI Key InChIKey=XTOLERVEHAIVDS-INIZCTEOSA-N

Data  5 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50140103   

TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140103((S)-1-(2,6-difluorobenzyl)-3-(2-(cyclopentylamino)...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140103((S)-1-(2,6-difluorobenzyl)-3-(2-(cyclopentylamino)...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity to human GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140103((S)-1-(2,6-difluorobenzyl)-3-(2-(cyclopentylamino)...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity evaluated by the ability to inhibit des-Gly10[125I]Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]- Gonadotropin-releasing hormone binding to cloned h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140103((S)-1-(2,6-difluorobenzyl)-3-(2-(cyclopentylamino)...)
Affinity DataKi:  50nMAssay Description:In vivo inhibition of monkey Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140103((S)-1-(2,6-difluorobenzyl)-3-(2-(cyclopentylamino)...)
Affinity DataKi:  7.50E+3nMAssay Description:In vivo inhibition of rat Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140103((S)-1-(2,6-difluorobenzyl)-3-(2-(cyclopentylamino)...)
Affinity DataIC50:  5.5nMAssay Description:In vitro inhibition of [Ca2+] influx in RBL cells expressing Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140103((S)-1-(2,6-difluorobenzyl)-3-(2-(cyclopentylamino)...)
Affinity DataIC50:  8.20nMAssay Description:Antagonist activity at human GnRHR assessed as inhibition of calcium flux by IP3 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed