BDBM50201026 CHEMBL3983077::US10155727, Example 17::USRE49517, Example 17

SMILES CCc1[nH]ncc1Cn1cc(cn1)-c1ccc(Cl)c(OC(F)F)c1

InChI Key InChIKey=IZRNPSABLKZTLN-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50201026   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201026(CHEMBL3983077 | US10155727, Example 17 | USRE49517...)
Affinity DataIC50:  3.50E+4nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201026(CHEMBL3983077 | US10155727, Example 17 | USRE49517...)
Affinity DataIC50:  56nMAssay Description:Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201026(CHEMBL3983077 | US10155727, Example 17 | USRE49517...)
Affinity DataIC50:  3.70E+3nMAssay Description:Antagonist activity at human NR2B expressed in HEK293 cells co-expressing NRI assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201026(CHEMBL3983077 | US10155727, Example 17 | USRE49517...)
Affinity DataIC50:  3.50E+4nMAssay Description:Binding was terminated by filtration of the incubated membrane preparations using Filtermat B (Pharmacia, Uppsala Sweden) and a Micro Cell Harvester ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201026(CHEMBL3983077 | US10155727, Example 17 | USRE49517...)
Affinity DataIC50:  3.70E+3nMAssay Description:The medium was removed and the cells were loaded with 200 μl loading buffer (Molecular Devices) in Mg2+-free HBPS containing 100 μM 7-CKA a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201026(CHEMBL3983077 | US10155727, Example 17 | USRE49517...)
Affinity DataIC50:  56nMAssay Description:After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201026(CHEMBL3983077 | US10155727, Example 17 | USRE49517...)
Affinity DataIC50:  56nMAssay Description:After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4° C. The pellet was resuspended in 5 ml of 5...More data for this Ligand-Target Pair
In DepthDetails US Patent