BDBM50214930 5-[1-biphenyl-4-yl-meth-(Z)-ylidene]-10-methoxy-2,2,4-trimethyl-2,4a,5,12a-tetrahydro-1H-6-oxa-1-aza-chrysen-9-ol::CHEMBL437556

SMILES COc1c(O)ccc2O\C(=C/c3ccc(cc3)-c3ccccc3)C3=C(C=CC4NC(C)(C)C=C(C)C34)c12

InChI Key InChIKey=ZBMDLEOBRDEIKO-VEILYXNESA-N

Data  1 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50214930   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214930(5-[1-biphenyl-4-yl-meth-(Z)-ylidene]-10-methoxy-2,...)
Affinity DataKi:  4.40nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214930(5-[1-biphenyl-4-yl-meth-(Z)-ylidene]-10-methoxy-2,...)
Affinity DataIC50:  77nMAssay Description:Activity at GR assessed as repression of TNFalpha and IL 1beta induced E-selectin responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214930(5-[1-biphenyl-4-yl-meth-(Z)-ylidene]-10-methoxy-2,...)
Affinity DataEC50: >1.00E+3nMAssay Description:Antagonist activity at GR assessed as inhibition of dexamethasone-induced GRE activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214930(5-[1-biphenyl-4-yl-meth-(Z)-ylidene]-10-methoxy-2,...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at GR by GRE activation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed