BDBM50216424 2-[1-(4-bromo-benzyl)-2-oxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1,2-dihydro-indol-3-yl-idene]-malononitrile::CHEMBL436989

SMILES Brc1ccc(-[#6]-[#7]-2-[#6](=O)\[#6](=[#6](\C#N)C#N)-c3cc(ccc-23)S(=O)(=O)[#7]-2-[#6]-[#6]-[#6]-[#6@H]-2-[#6]-[#8]-c2ccccc2)cc1

InChI Key InChIKey=XQVKFBHLQLXESM-QHCPKHFHSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50216424   

TargetCaspase-1(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50216424(2-[1-(4-bromo-benzyl)-2-oxo-5-(2-phenoxymethyl-pyr...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50216424(2-[1-(4-bromo-benzyl)-2-oxo-5-(2-phenoxymethyl-pyr...)
Affinity DataIC50:  840nMAssay Description:Inhibition of human recombinant caspase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50216424(2-[1-(4-bromo-benzyl)-2-oxo-5-(2-phenoxymethyl-pyr...)
Affinity DataIC50:  92.2nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50216424(2-[1-(4-bromo-benzyl)-2-oxo-5-(2-phenoxymethyl-pyr...)
Affinity DataIC50:  20.1nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50216424(2-[1-(4-bromo-benzyl)-2-oxo-5-(2-phenoxymethyl-pyr...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed