BDBM50232860 CHEMBL3125071::US11225469, Compound 23

SMILES Cc1cccc(NC(=S)N2CCN(CC2)c2cccc(c2)C(F)(F)F)c1

InChI Key InChIKey=FHKNYRDPAVRBFO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50232860   

TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Whitehead Institute For Biomedical Research

US Patent
LigandPNGBDBM50232860(CHEMBL3125071 | US11225469, Compound 23)
Affinity DataIC50: >2.00E+4nMAssay Description:PHGDH assay buffer contained 50 mM TEA pH 8.0, 10 mM MgCl2, 0.05% BSA, and 0.01% Tween-20. PHGDH enzyme buffer consisted of assay buffer with 20 nM P...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Whitehead Institute For Biomedical Research

US Patent
LigandPNGBDBM50232860(CHEMBL3125071 | US11225469, Compound 23)
Affinity DataIC50: >5.70E+4nMAssay Description:Inhibition of human liver N-terminal His6-tagged PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3 -phosphoglycerate as substarte measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed