BDBM50256350 CHEMBL4098863

SMILES Cc1[nH]c(-c2ccccc2Oc2ccc(Cl)cc2)cc1C(N)=O

InChI Key InChIKey=VYHWNVJEEBHTKR-UHFFFAOYSA-N

Data  1 KI  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50256350   

TargetBromodomain-containing protein 4(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50256350BDBM50256350(CHEMBL4098863)
Affinity DataEC50:  280nMAssay Description:Inhibition of BRD4 (unknown origin) expressed in human H1299 cells co-expressing HPV16-LCR/E2 after 24 hrs by Bright Glo-luciferase reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2019
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50256350BDBM50256350(CHEMBL4098863)
Affinity DataKi:  410nMAssay Description:Binding affinity to His-tagged BRD4 BD1-BD2 (K57 to K550 residues) (unknown origin) after 1 hr by Alexa-647-conjugated probe based TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2019
Entry Details Article
PubMed