BDBM50265920 4-((5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethynyl)benzoic acid::CHEMBL451835::US9963439, BE23
SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
InChI Key InChIKey=OQVLOWLEEHYBJH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50265920
Affinity DataEC50: 0.600nMAssay Description:Activity at human RARalpha ligand binding domain expressed in COS7 cells cotransfected with Gal4-DBD assessed as transcriptional activation after 16 ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Activity at human RARbeta ligand binding domain expressed in COS7 cells cotransfected with Gal4-DBD assessed as transcriptional activation after 16 h...More data for this Ligand-Target Pair
Affinity DataKd: 160nMAssay Description:Displacement of DC271 from CRABP2 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
TargetCytochrome P450 26A1(Homo sapiens (Human))
University of Washington Through Its Center For Commercialization
US Patent
University of Washington Through Its Center For Commercialization
US Patent
Affinity DataIC50: 1.05E+4nMAssay Description:Eighteen compounds were tested as potential inhibitors of CYP26A1 and CYP26B1. The formation of 9-cis-4-OH-RA metabolite was monitored and the percen...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
University of Washington Through Its Center For Commercialization
US Patent
University of Washington Through Its Center For Commercialization
US Patent
Affinity DataIC50: 1.22E+3nMAssay Description:Compounds were assessed for inhibition (IC50, n=2) of CYP2C8, CYP2C9 and CYP3A4 in pooled human liver microsomes using selective probe substrates at ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Activity at human RARgamma ligand binding domain expressed in COS7 cells cotransfected with Gal4-DBD assessed as transcriptional activation after 16 ...More data for this Ligand-Target Pair