BDBM50266426 CHEMBL4076808

SMILES [H][C@@]1(Cc2nc(no2)-c2ccc(Nc3nc(cs3)-c3cccc(c3)C(F)(F)F)cc2)CCCN1C(N)=N

InChI Key InChIKey=ONQQJVYCDMZBNG-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50266426   

TargetSphingosine kinase 2(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50266426(CHEMBL4076808)
Affinity DataKi:  90nMAssay Description:Inhibition of recombinant human SPHK2 at using sphingosine as substrate after 30 mins in presence of gamma-[32P]-ATP by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50266426(CHEMBL4076808)
Affinity DataKi:  120nMAssay Description:Inhibition of recombinant human SPHK1 using sphingosine as substrate after 30 mins in presence of gamma-[32P]-ATP by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50266426(CHEMBL4076808)
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed