BDBM50270667 CHEMBL4130194

SMILES C[C@H](Cc1ccccc1)C(=O)N2CCC(CC2)(CN3C=Nc4ccccc4C3=O)O

InChI Key InChIKey=BAMWYPCZJUTPAE-UHFFFAOYSA-N

Data  1 KI  8 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50270667   

TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50270667BDBM50270667(CHEMBL4130194)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of full length USP7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50270667BDBM50270667(CHEMBL4130194)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using ubiquintin-rhodamine as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50270667BDBM50270667(CHEMBL4130194)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of N-terminal double his-tagged catalytic domain human USP7 (208 to 560 residues) expressed in Escherichia coli BL21 (DE3) pLysS cells inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50270667BDBM50270667(CHEMBL4130194)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of USP7 (unknown origin) using GST-Ub52-flag substrate incubated for 1 hr by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50270667BDBM50270667(CHEMBL4130194)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human GST-tagged UCHL3 expressed in Escherichia coli assessed as cleavage of Ubiquitin-Rhodamine110-glycine to Ubiquitin and Rhodamine1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 47(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50270667BDBM50270667(CHEMBL4130194)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of USP47 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 1(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50270667BDBM50270667(CHEMBL4130194)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of His6-tagged human USP1 expressed in insect Sf21 cells coexpressing untagged UAF1 assessed as cleavage of Ubiquitin-Rhodamine110-glycine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 1(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50270667BDBM50270667(CHEMBL4130194)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of USP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 47(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50270667BDBM50270667(CHEMBL4130194)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of USP47 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed