BDBM50286733 CHEMBL4162312

SMILES CC(C)C(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3cc(F)ccc3n2C)CC1

InChI Key InChIKey=BRYOCFDMHMUJGE-PMERELPUSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50286733   

TargetBile acid receptor(Homo sapiens (Human))
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50286733(CHEMBL4162312)
Affinity DataIC50:  0.0600nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50286733(CHEMBL4162312)
Affinity DataIC50:  340nMAssay Description:Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed