BDBM50316277 6-(4-morpholino-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)pyridin-3-amine::CHEMBL1098311

SMILES Nc1ccc(nc1)-c1nc(N2CCOCC2)c2cnn(-c3ccccc3)c2n1

InChI Key InChIKey=AQZCUKHDRDMPLK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50316277   

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50316277BDBM50316277(6-(4-morpholino-1-phenyl-1H-pyrazolo[3,4-d]pyrimid...)
Affinity DataIC50: 145nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316277BDBM50316277(6-(4-morpholino-1-phenyl-1H-pyrazolo[3,4-d]pyrimid...)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of PI3Kalpha by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed