BDBM50329543 (R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-(3-(prop-1-ynyl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL1270934

SMILES CC#Cc1cccc(c1)[C@]1(N=C(N)N(C)C1=O)c1ccc(OC(F)F)cc1

InChI Key InChIKey=RIIMHERUTFJZHJ-HXUWFJFHSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50329543   

TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329543((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl...)
Affinity DataEC50:  70nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329543((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl...)
Affinity DataIC50: <100nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329543((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of renin by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329543((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl...)
Affinity DataIC50:  210nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329543((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl...)
Affinity DataIC50:  4.12E+3nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329543((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed