BDBM50329815 (Z)-N-ethyl-2-oxo-3-((4-(piperidin-1-ylmethyl)phenylamino)methylene)indoline-6-carboxamide::CHEMBL1272021

SMILES CCNC(=O)c1ccc2C(C=Nc3ccc(CN4CCCCC4)cc3)C(=O)Nc2c1

InChI Key InChIKey=LKYFRGLAQIPPHS-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50329815   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50329815((Z)-N-ethyl-2-oxo-3-((4-(piperidin-1-ylmethyl)phen...)
Affinity DataEC50:  376nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50329815((Z)-N-ethyl-2-oxo-3-((4-(piperidin-1-ylmethyl)phen...)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50329815((Z)-N-ethyl-2-oxo-3-((4-(piperidin-1-ylmethyl)phen...)
Affinity DataIC50:  69nMAssay Description:Inhibition of TGFbeta receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed