BDBM50334766 CHEMBL1642896::cis-(2S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-2-amine

SMILES CN[C@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc2C1

InChI Key InChIKey=KDERKEZKMQCRPQ-HIFRSBDPSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50334766   

TargetSodium-dependent serotonin transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334766(CHEMBL1642896 | cis-(2S,4S)-4-(3,4-dichlorophenyl)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334766(CHEMBL1642896 | cis-(2S,4S)-4-(3,4-dichlorophenyl)...)
Affinity DataIC50:  45nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334766(CHEMBL1642896 | cis-(2S,4S)-4-(3,4-dichlorophenyl)...)
Affinity DataIC50:  281nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334766(CHEMBL1642896 | cis-(2S,4S)-4-(3,4-dichlorophenyl)...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334766(CHEMBL1642896 | cis-(2S,4S)-4-(3,4-dichlorophenyl)...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334766(CHEMBL1642896 | cis-(2S,4S)-4-(3,4-dichlorophenyl)...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50334766(CHEMBL1642896 | cis-(2S,4S)-4-(3,4-dichlorophenyl)...)
Affinity DataIC50:  5.27E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334766(CHEMBL1642896 | cis-(2S,4S)-4-(3,4-dichlorophenyl)...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed