BDBM50340534 (S)-2-(1-(4-(2-fluoroethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)azetidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile::CHEMBL1762354

SMILES F[#6]-[#6]-[#8]-c1ccc(-[#6]-[#7]-2-[#6](=O)\[#6](=[#6](/C#N)C#N)-c3cc(ccc-23)S(=O)(=O)[#7]-2-[#6]-[#6]-[#6@H]-2-[#6]-[#8]-c2ccccc2)cc1

InChI Key InChIKey=ZNNUDGYAGWASQI-QHCPKHFHSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50340534   

TargetCaspase-1(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50340534((S)-2-(1-(4-(2-fluoroethoxy)benzyl)-2-oxo-5-(2-(ph...)
Affinity DataIC50:  4.78E+3nMAssay Description:Inhibition of caspase 1 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50340534((S)-2-(1-(4-(2-fluoroethoxy)benzyl)-2-oxo-5-(2-(ph...)
Affinity DataIC50:  22.4nMAssay Description:Inhibition of human caspase 3 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50340534((S)-2-(1-(4-(2-fluoroethoxy)benzyl)-2-oxo-5-(2-(ph...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of caspase 8 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50340534((S)-2-(1-(4-(2-fluoroethoxy)benzyl)-2-oxo-5-(2-(ph...)
Affinity DataIC50:  292nMAssay Description:Inhibition of caspase 7 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50340534((S)-2-(1-(4-(2-fluoroethoxy)benzyl)-2-oxo-5-(2-(ph...)
Affinity DataIC50:  747nMAssay Description:Inhibition of caspase 6 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed