BDBM50341041 1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1-methyl-1H-pyrazol-3-yl)-1H-benzo[d]imidazol-2-amine::CHEMBL1760159

SMILES Cc1nc(N)nc(n1)-n1c(Nc2ccn(C)n2)nc2ccccc12

InChI Key InChIKey=YGMCOBDMWUYNPQ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50341041   

TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341041BDBM50341041(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1-methy...)
Affinity DataIC50: 270nMAssay Description:Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341041BDBM50341041(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1-methy...)
Affinity DataIC50: 580nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of AKT at S473More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50341041BDBM50341041(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1-methy...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50341041BDBM50341041(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1-methy...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341041BDBM50341041(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1-methy...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of 4EBP1 at T37/46More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50341041BDBM50341041(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1-methy...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50341041BDBM50341041(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1-methy...)
Affinity DataIC50: 2.88E+4nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed