BDBM50341057 1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-1,2,4-triazol-3-yl)-1H-benzo[d]imidazol-2-amine::CHEMBL1760166

SMILES Cc1nc(N)nc(-n2c(Nc3nnc[nH]3)nc3ccccc32)n1

InChI Key InChIKey=WKVMHMOLOLXPPL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50341057   

TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341057BDBM50341057(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-1,2,...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of AKT at S473More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341057BDBM50341057(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-1,2,...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of 4EBP1 at T37/46More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341057BDBM50341057(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-1,2,...)
Affinity DataIC50: 3.31E+4nMAssay Description:Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed