BDBM50341072 3-(1-(4-(methylamino)-1,3,5-triazin-2-yl)-1H-benzo[d]imidazol-2-ylamino)phenol::CHEMBL1762775

SMILES CNc1ncnc(n1)-n1c(Nc2cccc(O)c2)nc2ccccc12

InChI Key InChIKey=UNHLMXLXZKTYPJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50341072   

TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341072BDBM50341072(3-(1-(4-(methylamino)-1,3,5-triazin-2-yl)-1H-benzo...)
Affinity DataIC50: 180nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of AKT at S473More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50341072BDBM50341072(3-(1-(4-(methylamino)-1,3,5-triazin-2-yl)-1H-benzo...)
Affinity DataIC50: 190nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341072BDBM50341072(3-(1-(4-(methylamino)-1,3,5-triazin-2-yl)-1H-benzo...)
Affinity DataIC50: 250nMAssay Description:Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341072BDBM50341072(3-(1-(4-(methylamino)-1,3,5-triazin-2-yl)-1H-benzo...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of 4EBP1 at T37/46More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed