BDBM50343848 (E/Z)-3-(1H-Imidazol-4-yl)propylbut-2-enylcarbamate hydrogenmaleate::CHEMBL1774589

SMILES CC=CCNC(=O)OCCCc1cnc[nH]1

InChI Key InChIKey=XGTMAMLGAGPZOD-UHFFFAOYSA-N

Data  2 KI  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50343848   

TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50343848((E/Z)-3-(1H-Imidazol-4-yl)propylbut-2-enylcarbamat...)
Affinity DataKi:  54nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO-K1 cells after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50343848((E/Z)-3-(1H-Imidazol-4-yl)propylbut-2-enylcarbamat...)
Affinity DataKi:  1.05E+3nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 subunit after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50343848((E/Z)-3-(1H-Imidazol-4-yl)propylbut-2-enylcarbamat...)
Affinity DataIC50:  128nMAssay Description:Antagonist activity against histamine H3 receptor in guinea pig ileum assessed as inhibition of electrically-evoked twitches after 30 mins in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50343848((E/Z)-3-(1H-Imidazol-4-yl)propylbut-2-enylcarbamat...)
Affinity DataKd:  6.92E+4nMAssay Description:Antagonist activity at histamine H1 receptor in guinea-pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed