BDBM50389064 CHEMBL2064349

SMILES Cn1c(Cc2nc(cc(=O)[nH]2)N2CCOCC2)nc2cc(ccc12)-c1ccccc1

InChI Key InChIKey=DNWQPQLERZVVAQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50389064   

LigandChemical structure of BindingDB Monomer ID 50389064BDBM50389064(CHEMBL2064349)
Affinity DataIC50: 6.75E+3nMAssay Description:Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50389064BDBM50389064(CHEMBL2064349)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus poly-His tagged human PI3Kgamma expressed in baculovirus infected insect sf9 cells using PI(4,5)P2 as substrate preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50389064BDBM50389064(CHEMBL2064349)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus poly-His tagged human PI3Kalpha expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Sanofi Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50389064BDBM50389064(CHEMBL2064349)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50389064BDBM50389064(CHEMBL2064349)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed