BDBM50394884 CHEMBL2165036::US8772480, 21

SMILES Nc1cc(nc(n1)C(F)(F)F)-c1cccnc1Nc1cccc2[nH]ncc12

InChI Key InChIKey=CNVZEXBATVQXBV-UHFFFAOYSA-N

Data  5 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50394884   

LigandChemical structure of BindingDB Monomer ID 50394884BDBM50394884(CHEMBL2165036 | US8772480, 21)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kbeta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50394884BDBM50394884(CHEMBL2165036 | US8772480, 21)
Affinity DataKi:  3.14E+3nMAssay Description:The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50394884BDBM50394884(CHEMBL2165036 | US8772480, 21)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kalpha expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50394884BDBM50394884(CHEMBL2165036 | US8772480, 21)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kgamma expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50394884BDBM50394884(CHEMBL2165036 | US8772480, 21)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kdelta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50394884BDBM50394884(CHEMBL2165036 | US8772480, 21)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant GST-tagged mTOR-mediated 4EBP1 phosphorylation after 90 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50394884BDBM50394884(CHEMBL2165036 | US8772480, 21)
Affinity DataIC50: 5.00E+4nMAssay Description:The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
US Patent