BDBM50432524 CHEMBL2349482

SMILES CN1C(N)=NC2(CC(C)(C)C(F)(F)c3ccc(cc23)-c2cncnc2)C1=O

InChI Key InChIKey=VCWNHNVDZQGTBB-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50432524   

TargetBeta-secretase 1(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50432524(CHEMBL2349482)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells using biotin-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50432524(CHEMBL2349482)
Affinity DataEC50:  1.88E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing wild type APP assessed as level of amyloid beta (1 to 40) after 48 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCathepsin D(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50432524(CHEMBL2349482)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of human spleen cathepsin D using 5-FAM/QXL as peptide substrate after 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed