BDBM50446279 CHEMBL3109201

SMILES Nc1nccc2c(cccc12)-c1ccc(NC(=O)Nc2cc(ccc2Cl)C(F)(F)F)cc1

InChI Key InChIKey=ZKOPOIXNUXDXMS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50446279   

LigandChemical structure of BindingDB Monomer ID 50446279BDBM50446279(CHEMBL3109201)
Affinity DataIC50: 630nMAssay Description:Inhibition of human N-terminal His-GST-TEV-fused RIP1 kinase domain (1 to 375) autophosphorylation expressed in baculovirus infected insect Sf9 cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50446279BDBM50446279(CHEMBL3109201)
Affinity DataIC50: 3.20E+3nMAssay Description:Displacement of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50446279BDBM50446279(CHEMBL3109201)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as prevention of TNFalpha/zVAD.fmk-induced necrotic cell death preincubated for 30 to 60 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed