BDBM50515201 CHEMBL4453693

SMILES C[C@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOCC1

InChI Key InChIKey=SYKBZXMKAPICSO-NSHDSACASA-N

Data  2 KI  2 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50515201   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50515201(CHEMBL4453693)
Affinity DataKi:  7.40nMAssay Description:Displacement of Alexafluor labelled kinase tracer314 from recombinant human C-terminal GST-tagged mTOR (1360 to 2549 amino acids) expressed in insect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50515201(CHEMBL4453693)
Affinity DataKi:  11nMAssay Description:Displacement of Alexafluor labelled kinase tracer314 from recombinant N-terminal His6-tagged PI3K p110alpha (unknown origin) incubated for 1 hr by FR...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50515201(CHEMBL4453693)
Affinity DataKd:  10nMAssay Description:Binding affinity to wild-type human partial length PIK3CG (S144 to A1102 residues) expressed in mammalian expression system by quantitative PCR based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50515201(CHEMBL4453693)
Affinity DataIC50:  74nMAssay Description:Inhibition of mTORC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50515201(CHEMBL4453693)
Affinity DataIC50:  68nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50515201(CHEMBL4453693)
Affinity DataKd:  0.840nMAssay Description:Binding affinity to wild-type human partial length PIK3CA (R108 to N1068 residues) expressed in mammalian expression system by quantitative PCR based...More data for this Ligand-Target Pair