BDBM50566278 CHEMBL4867353
SMILES OC(=O)c1cc(F)c(F)cc1NC(=O)c1ccc(nn1)-n1ccnc1
InChI Key InChIKey=WEBVQIJGIZVRGA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 50566278
Affinity DataKd: 526nMAssay Description:Binding affinity to N-terminal 6xHis-tagged human STING R232H mutant CTD extracted from Escherichia coli BL21(DE3) assessed as dissociation constant ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.39E+3nMAssay Description:Agonist activity at human 6His-tagged recombinant STING G230A/R293Q double mutant CTD (139 to 37 residues) expressed in Escherichia coli BL21 (DE3) i...More data for this Ligand-Target Pair
Affinity DataIC50: 1.49E+3nMAssay Description:Displacement of 5-FAM-labeled diABZI tracer from N-terminal 6xHis-tagged human STING G230A/R293Q mutant CTD extracted from Escherichia coli BL21(DE3)...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Agonist activity at mouse 6His-tagged recombinant STING CTD (144 to 378 residues) expressed in Escherichia coli BL21 (DE3) incubated for 10 mins by F...More data for this Ligand-Target Pair
Affinity DataIC50: 1.87E+3nMAssay Description:Displacement of 5-FAM-labeled diABZI tracer from N-terminal 6xHis-tagged wild-type mouse STING CTD extracted from Escherichia coli BL21(DE3) incubate...More data for this Ligand-Target Pair
Affinity DataEC50: 2.10E+3nMAssay Description:Agonist activity at STING in human THP-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Competitive inhibition of 5-FAM labelled diABZI binding to recombinant 6-his tagged mouse STING C-terminal domain (144 to 378 residues) expressed in ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.23E+3nMAssay Description:Agonist activity at STING in human THP1-Blue ISG cells harbouring SEAP reporter gene assessed as activation of cGAS-STING signaling pathway incubated...More data for this Ligand-Target Pair
Affinity DataEC50: 2.36E+3nMAssay Description:Agonist activity at STING in PMA-differentiated wildtype human THP1-Blue ISG cells harboring IRF-inducible SEAP reporter construct incubated for 24 h...More data for this Ligand-Target Pair
Affinity DataEC50: 3.03E+3nMAssay Description:Agonist activity at human STING in human THP1-Blue ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.07E+3nMAssay Description:Displacement of 5-FAM-labeled diABZI tracer from N-terminal 6xHis-tagged human STING R232H mutant CTD extracted from Escherichia coli BL21(DE3) incub...More data for this Ligand-Target Pair
Affinity DataIC50: 6.16E+3nMAssay Description:Agonist activity at human 6His-tagged recombinant STING R232H mutant CTD (139 to 37 residues) expressed in Escherichia coli BL21 (DE3) incubated for ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.80E+3nMAssay Description:Binding affinity to wild type human STING by HTRF based cGAMP competition assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.02E+3nMAssay Description:Agonist activity at human 6His-tagged recombinant STING R293Q mutant CTD (139 to 37 residues) expressed in Escherichia coli BL21 (DE3) incubated for ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.81E+3nMAssay Description:Agonist activity at human 6His-tagged recombinant wild type STING CTD (139 to 37 residues) expressed in Escherichia coli BL21 (DE3) incubated for 10 ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.01E+4nMAssay Description:Displacement of 5-FAM-labeled diABZI tracer from N-terminal 6xHis-tagged wild-type human STING CTD extracted from Escherichia coli BL21(DE3) incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 1.04E+4nMAssay Description:Displacement of 5-FAM-labeled diABZI tracer from N-terminal 6xHis-tagged human STING R293Q mutant CTD extracted from Escherichia coli BL21(DE3) incub...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human STING in STING knockout human THP1-Blue ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in PMA-differentiated human THP1-Dual KO-STING cells incubated for 24 hrs by QUANTI-Blue assayMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in mouse RAW-Lucia ISG-KO-STING cells harbouring SEAP reporter gene assessed as activation of cGAS-STING signaling pathway ...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human THP1-Dual KO-STING cells harbouring SEAP reporter gene assessed as activation of cGAS-STING signaling pathway incu...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in mouse RAW-Lucia ISG cells harbouring SEAP reporter gene assessed as activation of cGAS-STING signaling pathway incubated...More data for this Ligand-Target Pair
Affinity DataEC50: 1.35E+5nMAssay Description:Agonist activity at mouse STING in mouse RAW-Lucia ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: >2.00E+5nMAssay Description:Agonist activity at mouse STING in STING knockout mouse RAW-Lucia ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assayMore data for this Ligand-Target Pair