BDBM50584951 CHEMBL5092589

SMILES NC(=O)c1ccc(Nc2ncc(c(N[C@H]3CC[C@H](O)CC3)n2)C(F)(F)F)cn1

InChI Key InChIKey=WOTJZQMSLYWZGS-HOMQSWHASA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50584951   

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584951(CHEMBL5092589)
Affinity DataIC50:  18nMAssay Description:Inhibition of N-terminal GST tagged human recombinant wild type FLT-3 (564-993 residues) expressed in baculovirus infected Sf21 insect cells using TK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584951(CHEMBL5092589)
Affinity DataIC50:  337nMAssay Description:Inhibition of N-terminal GST tagged human recombinant cKit (544 residue) expressed in baculovirus infected Sf21 insect cells using TK peptide as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584951(CHEMBL5092589)
Affinity DataIC50:  9.30nMAssay Description:Inhibition of N-terminal GST tagged human recombinant FLT3 D835Y mutant (564 residue) expressed in baculovirus infected Sf21 insect cells using TK pe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed