BDBM50587689 CHEMBL5197229
SMILES [H][C@@]12COP(O)(=O)O[C@H]3[C@@H](O)[C@H](O[C@]3([H])COP(O)(=O)O[C@@H]([C@H](O1)n1cnc3c1nc(N)[nH]c3=O)[C@@H]2O)n1cnc2c(N)ncnc12
InChI Key InChIKey=XRILCFTWUCUKJR-FLQQXUEZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50587689
Affinity DataKd: 4nMAssay Description:Binding affinity to C-terminal domain human STING (139 to 379 residues) expressed in E. coli assessed as dissociation constant by isothermal titratio...More data for this Ligand-Target Pair
Affinity DataKd: 7.90E+4nMAssay Description:Binding affinity to STING (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
Affinity DataEC50: 19nMAssay Description:Agonist activity at STING in human L929 cells assessed as IFN-beta RNA level measured after 4 hrs by qRT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Agonist activity at human STING incubated for 3 hrs by fluorescence based analysisMore data for this Ligand-Target Pair
Affinity DataKd: 4.20E+4nMAssay Description:Binding affinity to C-terminal domain human STING (139 to 379 residues) assessed as dissociation constant by DSF methodMore data for this Ligand-Target Pair
Affinity DataEC50: 7.23E+3nMAssay Description:Agonist activity at STING in human 293T hSTING-R232 Cells incubated for 48 hrs by QUANTI-blue assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mus musculus)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataEC50: 7.01E+3nMAssay Description:Agonist activity at STING in mouse 293T Cells incubated for 48 hrs by QUANTI-blue assayMore data for this Ligand-Target Pair
Affinity DataEC50: 42nMAssay Description:Antagonist activity at STING (unknown origin) in L929 cells assessed as IFN-beta RNA level q-RTPCR analysisMore data for this Ligand-Target Pair
Affinity DataKd: 0.200nMAssay Description:Binding affinity to human STING (137 to 379 residues) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair