BDBM50616134 CHEMBL5394226

SMILES c1cc(cc(c1)Nc2cccc3c2CN(C3)C#N)C(F)(F)F

InChI Key InChIKey=YMCWQMXCTIOSFB-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50616134   

TargetTranscriptional enhancer factor TEF-1(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50616134(CHEMBL5394226)
Affinity DataIC50: 900nMAssay Description:Displacement of FAM- labeled YAP1 peptide (60 to 99 residues) from human TEAD1 (209 to 426 residues) expressed in Escherichia coli BL21 (DE3) cells i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-3(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50616134(CHEMBL5394226)
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of FAM- labeled YAP1 peptide (60 to 99 residues) from human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21 (DE3) cells i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50616134(CHEMBL5394226)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of FAM- labeled YAP1 peptide (60 to 99 residues) from human TEAD2 (217 to 447 residues) expressed in Escherichia coli BL21 (DE3) cells i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTranscriptional enhancer factor TEF-5(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50616134(CHEMBL5394226)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of TEAD3 (unknown origin) transfected in human HEK293 cells co-transfected with renilla plasmid assessed as inhibition of transcriptional ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50616134(CHEMBL5394226)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of TEAD2 (unknown origin) transfected in human HEK293 cells co-transfected with renilla plasmid assessed as inhibition of transcriptional ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTranscriptional enhancer factor TEF-3(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50616134(CHEMBL5394226)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of TEAD4 (unknown origin) transfected in human HEK293 cells co-transfected with renilla plasmid assessed as inhibition of transcriptional ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-1(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50616134(CHEMBL5394226)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of TEAD1 (unknown origin) transfected in human HEK293 cells co-transfected with renilla plasmid assessed as inhibition of transcriptional ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed